According to Elle Russ chronic disease started in China about 12,000 years ago with the development of agriculture and introduction of grains into the diet and they correspond to the reign of Shennong, the “Emperor of the Five Grains”. I think he’d get a bit of a bad rap today with all the inflammatory diseases linked to gluten and grains amongst other things. Poor Emperor Shennong! On the other hand.. he’d probably be a very wealthy man! I learned this reading Elle’s book The Paleo Thyroid Solution which I heard about when she was interviewed by Robb Wolf.